This is the question bouncing around my head. I only wonder because I've read two ends of the spectrum, opinion wise, for editors/agents.
First opinion, never use first person.
Second opinion, use whatever works for your piece.
The first opinion was strongly stated by an editor that shall go nameless, but if that's the case how did "Twilight" make it?
My opinion on POV is that it needs to be what first strikes you. What do you instinctively start out with? If you have to make an active choice and are unsure, maybe you should not write it down yet.
Here's a suggestion...take a page of something you've written and change it to the opposite POV and see just how uncomfortable you are. If you are comfortable with the change, then try the whole story!
Also, don't let people push you around and try to make you change your POV to make it more sell-able...if they have to ask that then they aren't right for you (agents/publishers).
Stick to your guns xD